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I have a 41 year old female friend who uses Lexapro (anti-depressant) daily. I am concerned that prolonged use may have negative effects. What are some side-effects of prolonged use of this drug? Any advice on how to stop using it without terrible effects? Thanks for any advice. Answers : LEXAPRO IS A GOOD ANTIDEPRESSANT AND SHOULD NOT HAVE ANY MAJOR SIDE EFFECTS FROM TAKING IT..IT'S SIDE EFFECT PROFILE IS REALLY GOOD! lexapro is one of the better tolerated antidepressants. I find that when suffering from anxiety or depression like I am, taking it one day at a time and worrying about "prolonged effects" etc. really only impeeds healing. If it is making your friend feel more normal, then that's awesome. Lexapro is usually taken for 6 months to 2 years, depending on the person's issues. There are far few side effects with this anti depressant with most. If she stops taking it, you have to decrease the dosage very slowly and under a doctor's care. 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