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If you are on one (Lexapro 30mg) and Dr wants you to try another (75mg Effexor) and you do it suddenly (one day take Lex the next day take the effexor) what should you expect to happen? Becasue your seretonin levels are medicated already, will the withdrawal/buildup of the drugs effect you less? Answers : I take lexapro (40 mg) and my doctor wanted me to go onto wellbutrin as well. nothing happened for a few weeks though. so i'm pretty sure that even though you have the medication already in your bloodstream it will take time for the new medicine to get integrated as well. it's possible you can see psychological side effects though, like taking the new medicine and expecting it to help, so you believe that it does. but medically and scientifically speaking, a change in drugs will not usually produce side effects instantaneously. each individual experiences the effects of anti-depressents differently. 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